C1625

Image

1 of 1

C1625

Sigma

 

L-Canavanine

≥98% (TLC), powder, from Canavalia ensiformis

Synonym:L-α-Amino-γ-(guanidinooxy)-n-butyric acid
CAS Number:543-38-4
Linear Formula:C5H12N4O3
Molecular Weight:176.17
MDL number:MFCD00055781
PubChem Substance ID:24892427

Details

Related Products

References

Reviews

Description

Biochem/physiol ActionsA naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). Overproduction of NO by iNOS plays a crucial role in the pathophysiology of septic shock and chronic inflammation.

Properties

biological source from Canavalia ensiformis
assay≥98% (TLC)
formpowder
solubilityH2O: <100 mg/mL
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXn
Risk Statements20/21/22
Safety Statements36
WGK Germany3
RTECSES7002000

References

referenceLevy, B., et al., Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats. Shock 11, 98-103, (1999)
 Knowles, R.G., and Moncada, S., Nitric oxide synthases in mammals. Biochem. J. 298, 249-258, (1994)
 Anfossi, G., et al., Modulation of human platelet function by L-canavanine: differential effects of low and high concentrations. Gen. Pharmacol. 32, 321-328, (1999)